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To stop cancer's spread, take out its communication channels

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Metastasis - or the spread of cancer from one part of the body to other parts - accounts for more than 90 percent of cancer-related deaths. Although the cells that seed metastasis and the sites that they tend to travel to have been increasingly studied over the years, little has been known about how cancer migrates from a primary site, such as breast tissue, to a secondary site, such as the brain or bone marrow. A study by researchers from Brigham and Women's Hospital (BWH), published in Nature Communications, offers a new view of how cancer cells extend their reach, co-opting and transforming normal cells through "metastatic hijacking." The researchers also find that in pre-clinical models, pharmacological intervention can prevent this hijacking from occurring, pointing to new therapeutic targets for preventing cancer cells from spreading.

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